Understanding novel viral host interactions that modulate innate immunity

致命病毒如冠状病毒（MERS、SARS-CoV-1、SARS-CoV-2）、登革热、寨卡病毒、亨德拉病毒和尼帕病毒通过抑制宿主免疫系统发展了有效的复制机制。在这里，我们将研究病毒如何执行这些免疫逃避功能，并测试可以以高度特异性方式预防这些作用的抗病毒药物。如果这一想法能够得到证实，它将为开发新的抗病毒药物提供巨大的希望，同时将对细胞的毒性作用降至最低。

Lethal viruses such as coronaviruses (MERS, SARS-CoV-1, SARS-CoV-2), Dengue, Zika, Hendra, and Nipah have developed effective mechanisms of replication by dampening the host immune system. Here we will examine how viruses carry out these immune evasion functions, and test antiviral drugs that can prevent these effects in a highly specific manner. If this idea can be proved, it will provide great promise for the development of new antivirals whilst minimising the toxic effects to the cell.