Understanding the role of the metalloprotease ADM-4/ADAM17/TACE in promoting axonal repair

手术修复受损轴突并恢复功能的能力仍然是神经外科的一个重大挑战。然而，在无脊椎动物中已经观察到一种自发的修复机制，轴突融合，通过这种机制，横断轴突的两个分离的末端融合在一起。我们已经确定了一个分子，作为一个主调节轴突融合的线虫C。优雅在这里，我们将研究这种分子及其在哺乳动物神经元中控制轴突修复的潜力。

The ability to surgically repair an injured axon and restore function is still a significant challenge in neurosurgery. However, a spontaneous repair mechanism, axonal fusion, by which the two separated ends of a transected axon are fused back together, has been observed in invertebrates. We have identified a molecule that acts as a master regulator of axonal fusion in the nematode C. elegans. Here, we will study this molecule and its potential to control axonal repair in mammalian neurons.