Understanding steroid-resistance in severe asthma

虽然许多哮喘病例是轻度的，但严重的病例需要大量的卫生保健资源，并且对常规治疗几乎没有反应。该项目将研究从气道释放的特定化合物是否能够导致肺损伤和类似于严重哮喘的气道异常。我们将研究这些变化是否对常规治疗有反应，并研究在严重哮喘中恢复这种反应性的潜在治疗方法。

While many cases of asthma are mild, severe cases require extensive health care resources and are virtually unresponsive to conventional treatment. This project will investigate whether specific compounds released from the airway are able to cause lung damage and airway abnormalities similar to that in severe asthma. We will investigate whether these changes are responsive to conventional therapy and investigate a potential treatment for regaining this responsiveness in severe asthma.