Unravelling amygdala-hippocampus neural circuitry of anxiety: Role of adult-born neurons

新神经元的增加是大脑功能和可塑性的主要调节器，并且在海马体中被很好地理解。我们已经发现，新的神经元也在杏仁核中产生，杏仁核是一个处理情感记忆的区域。使用动物模型，我们可以识别和操纵这两个区域中的成年神经元，我们将评估它们对大脑神经回路的贡献及其在焦虑相关疾病的发病机制和治疗中的作用。

The addition of new neurons is a major regulator of brain function and plasticity, and is well understood in the hippocampus. We have discovered that new neurons are also generated in the amygdala, a region that processes emotional memories. Using animal models in which we can identify and manipulate adult-born neurons in these two regions, we will assess their contribution to the neural circuitry of the brain and their role in the pathogenesis and treatment of anxiety-related disorders.