Unravelling how protein signalling networks integrate to control T cell fate

合理设计药物组合以操纵免疫反应需要了解不同信号如何共同控制细胞行为。已知PIM激酶蛋白调节免疫细胞的重要特性，包括分裂和死亡，并且当失调时可导致癌症。我将进行一个全面的，公正的调查如何PIM激酶与其他蛋白质信号通路相互作用，以控制健康和疾病的免疫反应。

Rational design of drug combinations to manipulate the immune response requires an understanding of how different signals work together to control cell behaviour. The PIM kinase proteins are known to regulate important properties of immune cells, including division and death and when dysregulated can lead to cancer. I will perform a comprehensive, unbiased investigation of how the PIM kinases interact with other protein signalling pathways to control the immune response in health and disease.