Unravelling how protein signalling networks integrate to control T cell fate

合理设计药物组合以操纵免疫反应，需要了解不同的信号如何共同作用来控制细胞行为。众所周知，PIM激酶蛋白可以调节免疫细胞的重要特性，包括分裂和死亡，当调节失调时，可能会导致癌症。我将对PIM激酶如何与其他蛋白质信号通路相互作用以控制健康和疾病中的免疫反应进行全面、公正的研究。

Rational design of drug combinations to manipulate the immune response requires an understanding of how different signals work together to control cell behaviour. The PIM kinase proteins are known to regulate important properties of immune cells, including division and death and when dysregulated can lead to cancer. I will perform a comprehensive, unbiased investigation of how the PIM kinases interact with other protein signalling pathways to control the immune response in health and disease.