Using Bioengineered 3D Models to Replicate the Tumour Microenvironment in Prostate Cancer

这项研究将通过建立一种包含大量脂肪细胞的新型3D生物工程骨模型来解决晚期前列腺癌骨转移患者预后不良的问题，癌细胞可以在其中重新定位。这种方法将有助于确定脂肪细胞对癌细胞功能的影响，并有助于确定脂肪细胞是否是合法的治疗靶点，最终帮助临床医生选择更好的前列腺癌骨转移治疗方法。

The research will address the poor prognosis of patients with advanced prostate cancer bone metastasis by establishing a novel 3D bioengineered bone model containing high amounts of fat cells, where cancer cells can relocate. This approach will help identifying the impact of fat cells on cancer cell function, and help determine whether fat cells are legitimate therapeutic targets, ultimately assisting clinicians to select better therapies for prostate cancer bone metastasis.