Using nanotechnology to improve the therapeutic efficacy of iron chelators

铁负荷紊乱(如地中海贫血症)是人类疾病的一种重要类别。作为这些疾病治疗的一部分，需要去除铁，这通常是使用被称为铁络合剂的铁结合药物来完成的。目前的螯合剂由于副作用或繁琐的给药方法而不是理想的。该项目的目标是利用纳米技术开发更有效的提供螯合剂的方法，以提高其有效性并降低毒性。

Iron loading disorders (such as thalassaemia) represent an important class of human disease. As part of the treatment for these diseases, the iron needs to be removed and this is often done using iron-binding drugs known as iron chelators. Current chelators are not ideal due to side effects or onerous delivery methods. The goal of this project is to use nanotechnology to develop more effective ways of delivering chelators to improve their effectiveness and reduce toxicity.