Using a novel assay that detects antigen specific CD4+ and regulatory T cells to further understand reconstitution of antigen specific immune response post anti-retroviral therapy in subjects with HIV and in the diagnosis of latent TB

艾滋病毒治疗开始后免疫系统恢复的过程尚不清楚。我们将使用一种新的测试来监测免疫系统识别和反应不同抗原的能力，以了解影响HIV治疗患者免疫恢复的因素。我们还将评估这种新的测试在潜伏性结核病诊断中的应用。检测的改进将导致潜伏性结核病的治疗，从而减少活动性结核病病例。

The process by which the immune system recovers after commencement of therapy for HIV is not well understood. We will use a new test to monitor the immune system's ability to recognise and react to different antigens inorder to understand the factors that affect immune recovery in patients on therapy for HIV. We will also evaluate the use of this new test in the diagnosis of latent TB. Improvement in detection will lead to treatment of latent TB thus reduction of cases of active TB.