Vaccination against herpesvirus entry

疱疹病毒感染大多数澳大利亚人，并导致复发性溃疡，出生缺陷和癌症。感染持续终身，并传播给密切接触者，但没有明显的临床症状。因此，疾病很难预防。然而，我们可以从相关的动物感染中学到很多东西。我们已经证明，小鼠和人类疱疹病毒都是通过鼻细胞进入小鼠体内的。因此，人类感染可能遵循相同的途径。我们将确定什么样的身体防御在这里工作，以及疫苗是否可以预防感染。

Herpesviruses infect most Australians and cause recurrent ulcers, birth defects and cancer. Infection lasts lifelong, and spreads to close contacts without obvious clinical signs. Thus disease is hard to prevent. However we can learn much from related animal infections. We have shown that both mouse and human herpesviruses enter mice via cells in the nose. Thus human infections might follow the same route. We will define what body defences work here and whether vaccines can prevent infection.