Studies in organic, bio-organic and medicinal chemistry

有机化学是一门研究生命物质和维持生存的生理过程的科学。有机小分子的合成一直是制药业的基础，几十年来提供了神奇的药物来对抗各种疾病。学术研究通过描绘结构、性质和功能之间的关系的基础工作促进了这一过程。在这一过程中，为青年男女提供了出色的培训，他们继续在制药和生物技术公司中为更有针对性和更注重疾病的研究做出重大贡献，目的是发现更好的药物。多年来，我在蒙特利尔大学的研究小组在培训高素质人员方面产生了重大影响。在近300名集团校友中，有那些与各自公司一起负责发现和开发新药和有效药物的人。那些选择了学术生涯的人在培养自己的学生方面延续了卓越的传统。多年来，我的团队参与了多个领域的研究，可以说是生物启发和化学驱动。一个特别有价值的活动是合成药物(即药剂)原型，作为概念证明，具有抗癌、心血管疾病、细菌和病毒感染以及阿尔茨海默病等方面的良好活性。行业合作伙伴从这一点上受益匪浅。

Organic Chemistry is the science that deals with living matter and the physiological processes that sustain survival. The synthesis of small organic molecules has been the foundation of the pharmaceutical industry having provided miracle drugs to combat a wide-cross section of diseases over many decades. Academic research has contributed to this process through basic work delineating the relationship between structure, property and function. In the process, excellent training is provided to young men and women who go on to contribute in a significant way to more target- and disease-oriented research in pharmaceutical and biotech companies with the objective of discovering better medicines. My research group at the University of Montreal has had a significant impact in the training of highly qualified personnel over the years. Among the nearly 300 group alumni are those who were responsible for the discovery and development of new and effective medicines with their respective companies. Those who have chosen an academic career have continued the tradition of excellence in training their own students. Over the years, my group has been involved in diverse areas of research that can be described as biology-inspired and chemically-driven. A particularly rewarding activity has been the synthesis of drug (i.e. medicinal agent) prototypes as proofs of concept with promising activities against cancer, cardiovascular disease, bacterial and viral infection, and Alzheimer's disease among others. Industrial collaborating partners have greatly benefitted from this.