Development of advanced photoacoustic, photothermal and photocarrier techniques and biosensors for biomedical, dental and optoelectonic diagnostics

拟议的研究包括四个不同的领域：1a）半导体硅污染研究和1b）硅太阳能电池诊断使用激光光载波辐射测量（PCR），调制电致发光（MEL）和动态锁定PCR和MEL成像（PCRI和MELI）技术。2)一个潜在的突破性的亚表面深度选择仪器技术的发展，非线性光声雷达/声纳（PAR）层析成像的高对比度，信噪比和分辨率的深亚表面成像的软组织中的癌性病变。当完全开发时，这项技术有可能提供超声质量的图像分辨率，并以一小部分的成本提供健康和癌组织之间的对比度，与磁共振成像（MRI）相媲美。3)光热辐射（PTR）和调制发光（LUM）联合锁定成像技术的发展，用于实时评估极早期龋齿病变。两台相机将用于捕获LUM（近红外相机）和PTR（热红外相机）的多频图像。该牙科成像项目的成功可能会导致突破性的安全牙科临床成像技术，以在临床环境中与电离X射线照片竞争。 4)开发光声-发光雷达/声纳和新型光热辐射计-发光雷达，用于在地球上和空间微重力失重环境中进行极早期骨质疏松症（废用性骨质疏松症）诊断。拟议的研究计划旨在：（1）通过改进工艺质量控制，提高加拿大在工业电子和替代能源技术方面的竞争力;（2）开发突破性技术和生物传感器仪器，以便尽早发现乳腺癌病变、骨质疏松症和龋齿脱矿等广泛传播的疾病;以及（3）在加拿大积极参与并必须继续在国际上竞争的关键工业和卫生部门领域，或在加拿大应该找到竞争机会的新增长领域，为HQP提供多学科问题的高级培训。

The proposed research encompasses four distinct areas: 1a) semiconductor silicon contamination studies and 1b) Si solar-cell diagnostics using the technique of laser Photo-Carrier Radiometry (PCR), modulated electroluminescence (MEL) and dynamic lock-in PCR and MEL imaging (PCRI and MELI). 2) The development of a potentially breakthrough subsurface depth-selective instrumentation technique, the non-linear photo-acoustic radar/sonar (PAR) tomography for high-contrast, signal-to-noise ratio and resolution of deep subsurface imaging of cancerous lesions in soft tissues. When fully developed, this technology has the potential to deliver ultrasonic-quality image resolution, and to provide contrast between healthy and cancerous tissues rivaling that of magnetic resonance imaging (MRI) at a fraction of the cost. 3) The development of a combined photothermal radiometric (PTR) and modulated luminescence (LUM) lock-in imaging technique for real-time assessment of very early dental carious lesions. Two cameras will be used to capture multi-frequency images of LUM (near-IR camera) and of PTR (thermal-IR camera). The success of this dental imaging project may lead to a breakthrough safe dental clinical imaging technology to compete with ionizing X-radiographs in clinical settings. 4) The development of photoacoustic-luminescence radar/sonar (PAR-LUM) and a novel photothermal radiometric (PTR)-luminescence (LUM) radar, for very early bone osteoporosis diagnosis on Earth and in the weightless environment of space microgravity (disuse osteoporosis). The proposed research program is aimed at (1) boosting Canadian competitiveness in industrial electronics and alternative energy technologies through improved process quality control; (2) developing breakthrough techniques and biosensor instrumentation for the earliest possible detection of widespread diseases such as breast cancerous lesions, osteoporosis and dental demineralization caries; and (3) offering advanced training of HQP in multidisciplinary problems in key industrial and health sector areas in which Canada has an active presence and must continue competing internationally, or in new growth fields in which it should find opportunities to compete.