Medicinal inorganic chemistry

我们实验室的研究项目研究金属离子在疾病的病因、诊断和治疗中的作用。这些项目包括各种金属离子、广泛的配基系统、全面的技术和合作以及各种资金支持来源。有机配体和无机络合物的合成以及物理(电位滴定、分光光度滴定、EPR、电化学、核磁共振、MS等)在研究方案中进行了生物学研究。这种方法的成功是双(乙基麦芽糖)氧钒(IV)(也称为BEOV或AKP-020)即将进入IIa期临床试验(www.akesis.com)-基础NSERC-和CIHR资助的配位化学和药理学研究已经产生了一种临床研究药物和潜在的口服疗法。

Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions, broad spectrum of ligand systems, panoply of techniques and collaborations, and various sources of financial support. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, EPR, electrochemistry, NMR, MS etc.) and biological studies are undertaken in the research programme. The success of this approach is the imminent entry of bis(ethylmaltolato)oxovanadium(IV) (also known as BEOV or AKP-020) into a phase IIa clinical trial in type 2 diabetes (www.akesis.com) - basic NSERC- and CIHR-funded research in coordination chemistry and pharmacology has yielded a clinically studied drug and potential oral therapy.