Cyclophane Carbene Complexes as Catalysts: An Integrated Synthetic, Structural, and Mechanistic Approach

作为催化剂的环番卡宾络合物：综合合成、结构和机理方法。金属-卡宾配合物是新兴的高效催化剂，用于对制药和精细化学品工业极其重要的化学过程。该项目将建立在最近发现的一系列络合物的基础上，这些络合物在碳-碳键形成反应中表现出金属-卡宾催化剂的最高活性。深入了解新催化剂的工作方式将通过合成，机理和结构研究的组合获得。这种结构/反应性关系的详细研究将提供对这些催化剂如此有效的原因的理解，从而为开发适合工业应用的上级新催化剂提供合成线索。

Cyclophane Carbene Complexes as Catalysts: An Integrated Synthetic, Structural, and Mechanistic Approach. Metal-carbene complexes are emerging as efficient catalysts for chemical processes of immense importance to the pharmaceutical and fine chemicals industries. This project will build on the recent discovery of a family of complexes that exhibits the highest activity yet reported for metal-carbene catalysts in carbon-carbon bond-forming reactions. Insights into the ways the new catalysts work will be gained through a combination of synthetic, mechanistic, and structural studies. This detailed investigation of structure/reactivity relationships will provide an understanding of why these catalyst are so efficient and hence give synthetic leads for the development of superior new catalysts suitable for industrial application.