Development of Multivalent Hyaluronan Derivative Therapeutics

多价海洛烷衍生物治疗药物的开发。透明质酸受体CD44的过表达已经在疾病如癌症、牛皮癣、关节炎和哮喘的病理部位被鉴定。该提案中描述的研究旨在开发靶向CD44的新型治疗化合物，同时引发治疗指数。这些新疗法的设计基于模板结构，其中包含已知的细胞毒性或抗真菌剂以及透明质酸（一种自然界中普遍存在的天然碳水化合物）。

Development of Multivalent Hyaluronan Derivative Therapeutics. Over-expression of the hyaluronan receptor CD44 has been identified at pathological sites of diseases such as cancer, psoriasis, arthritis and asthma. The research described in this proposal aims to develop novel therapeutic compounds which target CD44 whilst eliciting a therapeutic index. The design of these new therapeutics is based on a template structure which incorporates known cytotoxic or anti-fungal agentsas well as hyaluronan, a naturally occurring carbohydrate, ubiquitous in nature.