Enantioselective catalyis and total synthesis of alkaloids

我们正在开发合成手性化合物的新方法。手性化合物在医药和精细化学工业中都非常重要。例如，全球手性药物的销售额远远超过1000亿美元。NSERC资助的拟议研究的前半部分集中在开发新型手性催化剂上。发现更好的催化剂对于改进制造上述化合物的方法至关重要。最终，如果我们的研究被证明是成功的，或许能够降低制造人类药物和其他重要化学品的成本。我们NSERC提案的后半部分描绘了一条新的合成路线，以获得一类在人类身上表现出非常有希望的治疗特性的分子。这一领域的研究有朝一日可能会导致开发出更好的治疗严重疾病的药物。NSERC的拨款还使制药和其他相关化学工业所需的高素质化学家的培训成为可能。

We are developing new methods for the synthesis of chiral compounds. Chiral compounds are extremely important to both the pharmaceutical and fine chemical industries. For example, worldwide sales of chiral drugs are well over a hundred billion dollars. The first half of proposed NSERC-funded research focuses on the development of new classes of chiral catalysts. The discovery of better catalysts is crucial to improving the ways in which the afore-mentioned compounds can be made. Ultimately, our research, if proven successful, might be able to lower the cost of manufacturing human pharmaceuticals and other important chemicals. The second half of our NSERC proposal delineates a new synthetic route to a class of molecules that exhibit very promising therapeutic properties in humans. Research in this field might one day lead to the development of better medicines for the treatment of serious ailments. The NSERC grant also enables the training of highly qualified chemists that are required in the pharmaceutical and other allied chemical industries.