Discovery Projects - Grant ID: DP0208662

动态超分子组合文库的特征和发展生物活性分子的发现，特别是药物的发现，需要设计和合成选择性地与生物靶标结合的宿主分子。组合化学极大地帮助了这一发现过程，因为它允许快速筛选大量分子。在这项提议中，金属离子相互作用将在组合库中使用，因为这将极大地增加要筛选活性的化合物池的多样性。了解如何生成和分析这些文库在药物筛选、发现新的底物、酶和抑制剂方面具有潜在的应用。

Characterisation and Development of Dynamic Supramolecular Combinatorial Libraries. The discovery of biologically active molecules, in particular drug discovery, requires the design and synthesis of host molecules that bind selectively to the biological target. Combinatorial chemistry has greatly assisted this discovery process as it allows the rapid screening of large collections of molecules. In this proposal, metal ion interactions will be used in the combinatorial library as this will greatly increases the diversity of the pool of compounds to be screened for activity. Understanding how to generate and analyze these libraries has potential applications in drug screening, the discovery of new substrates, enzymes and inhibitors.