Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation

蛋白质和天然产物表征的连字符分离/质谱技术。该提案巩固了三家机构在ACROSS（澳大利亚分离科学研究中心）倡议上的合作，为涉及高分辨率蛋白质和天然产物表征的复杂样品的化学结构分析提供基础技术。所要求的设备支持重要的新目标分子的完整表征。GCxGC-TOFMS技术将验证我们新获得专利的多维分离技术。Q-TOF-TOFMS技术，新颖的专利蛋白质预分离方法，以及具有高分辨率表征/鉴定新目标蛋白的样品处理，允许先进的蛋白质组学发展。蛋白质组学依赖于复杂的质谱技术。这些技术将：&#183；增强这些科学在澳大利亚东南部地区的能力和专业知识；&#183；确保ACROSS计划获得具有国际竞争力的研究能力；在与蛋白质、精油和其他天然（生物）物质分析相关的领域提供商业终端。

Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation. This proposal consolidates the 3 institutions' collaboration on the ACROSS (Australian Centre for Research on Separation Science) initiative, providing fundamental technology for chemical structural analysis of complex samples involving high resolution protein and natural product characterisation. Requested equipment supports complete characterisation of important novel target molecules. GCxGC-TOFMS technology will validate our newly patented multidimensional separation techniques. Q-TOF-TOFMS technology, novel patented protein prefractionation approaches, and sample handling with high resolution characterisation / identification of new target proteins allows advanced proteomics developments. Proteomics depends critically upon sophisticated MS techniques. These technologies will: ·enhance the capabilities and expertise in these sciences in the SE Australian area; ·ensure the ACROSS initiative achieves internationally competitive research capabilities; ·provide commercial endpoints in fields associated with analysis of proteins, essential oils and other natural (bio)substances.