MRI: Acquisition of a Quadrupole/Time-of-Flight Mass Spectrometer with Ion Mobility Separations for Faculty and Student Research in the Susquehanna Valley

该奖项由主要研究仪器和化学研究仪器项目支持。巴克内尔大学正在获得高压液相色谱仪离子迁移率四极质谱计（hplc - imm - q - tof），以支持Susquehanna大学的Douglas Collins教授及其同事Moria Chambers和Lou Tom。一般来说，质谱（MS）是用于鉴定和表征复杂样品中嵌入的少量化学物质的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被制成离子，并测量离子的质量。这种高度灵敏的技术可以研究复杂混合物中的分子结构。带有液相色谱仪的仪器可以在混合物到达质谱仪分析仪之前将其分离。离子迁移率（IM）组件提供了一种基于它们与气体的相互作用（取决于它们的质量）分离气相离子的方法。最初，离子被迅速分离，然后它们被引入质量分析仪。这种复杂的仪器可用于分析人体样品（蛋白质组学和代谢组学）。此次收购加强了大学和地区的研究基础设施。该仪器通过使不同的学生熟悉这一现代分析技术，扩大了参与范围。高效液相色谱- im - q - tof还用于涉及萨斯克汉纳大学学生的外展活动。颁发质谱仪的目的是为了加强各级的研究和教育。它特别影响了超分子主客体化学的探索以及多孔和结晶共价有机框架（COF）形成的机理研究。该仪器用于通过金属相互作用控制肽的二级结构。此外，它还为理解复杂有机膜的多相化学提供了信息。质谱计用于探索三手烟对室内表面的影响，并用于药物光降解的研究。该仪器也用于萤火虫抗菌剂的鉴定。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Bucknell University is acquiring a high-pressure liquid-chromatograph ion mobility, quadrupole mass spectrometer (HPLC-IM-Q-TOF) to support Professor Douglas Collins and colleagues Moria Chambers and Lou Tom from Susquehanna University. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are made into ions and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer's analyzer. The ion mobility (IM) component provides a method that separates gas phase ions based on their interactions with a gas depending on their masses. Initially, the ions are quickly separated and then they are introduced into the mass analyzer. This complex instrument is useful to analyze samples from the human body (proteomics and metabolomics). The acquisition strengthens the research infrastructure at the university and regional area. The instrument broadens participation by enabling diverse students to gain familiarity with this modern analytical technique. The HPLC-IM-Q-TOF is also used in outreach activities involving students from Susquehanna University.The award of the mass spectrometer is aimed at enhancing research and education at all levels. It especially impacts exploration of supramolecular host-guest chemistry and mechanistic studies of porous and the formation of crystalline covalent organic frameworks (COF). The instrumentation is used for controlling peptide secondary structure through metal interactions. In addition, it provides information to understand multiphase chemistry of complex organic films. The mass spectrometer is used to explore the effect of third hand smoke on indoor surfaces and for the study of photodegradation of pharmaceuticals. This instrument is also used in the identification of antimicrobials in fireflies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.