MRI: Acquisition of a Quadrupole/Time-of-Flight Mass Spectrometer with Ion Mobility Separations for Faculty and Student Research in the Susquehanna Valley

MRI：为萨斯奎哈纳山谷的教师和学生研究购买具有离子淌度分离功能的四极杆/飞行时间质谱仪

• 批准号: 2018547
• 负责人: Douglas Collins
• 金额: $ 39.15万
• 依托单位: Bucknell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018547&HistoricalAwards=false
• 关键词: MRI; Acquisition; Quadrupole; Time; Flight

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Bucknell University is acquiring a high-pressure liquid-chromatograph ion mobility, quadrupole mass spectrometer (HPLC-IM-Q-TOF) to support Professor Douglas Collins and colleagues Moria Chambers and Lou Tom from Susquehanna University. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are made into ions and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer's analyzer. The ion mobility (IM) component provides a method that separates gas phase ions based on their interactions with a gas depending on their masses. Initially, the ions are quickly separated and then they are introduced into the mass analyzer. This complex instrument is useful to analyze samples from the human body (proteomics and metabolomics). The acquisition strengthens the research infrastructure at the university and regional area. The instrument broadens participation by enabling diverse students to gain familiarity with this modern analytical technique. The HPLC-IM-Q-TOF is also used in outreach activities involving students from Susquehanna University.The award of the mass spectrometer is aimed at enhancing research and education at all levels. It especially impacts exploration of supramolecular host-guest chemistry and mechanistic studies of porous and the formation of crystalline covalent organic frameworks (COF). The instrumentation is used for controlling peptide secondary structure through metal interactions. In addition, it provides information to understand multiphase chemistry of complex organic films. The mass spectrometer is used to explore the effect of third hand smoke on indoor surfaces and for the study of photodegradation of pharmaceuticals. This instrument is also used in the identification of antimicrobials in fireflies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。巴克内尔大学正在购买一台高压液相色谱离子迁移率四极质谱仪（HPLC-IM-Q-TOF），以支持道格拉斯柯林斯教授和来自萨斯奎汉纳大学的同事莫里亚·钱伯斯和卢·汤姆。一般来说，质谱（MS）是用于识别和表征复杂样品中嵌入的少量化学物质的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被制成离子，并测量离子的质量。这种高灵敏度的技术可以研究复杂混合物中的分子结构。带有液相色谱仪的仪器可以在化合物到达质谱仪的分析仪之前分离化合物的混合物。离子迁移率（IM）组件提供了一种基于气相离子与气体的相互作用（取决于其质量）分离气相离子的方法。最初，离子被快速分离，然后它们被引入质量分析仪。这种复杂的仪器可用于分析人体样品（蛋白质组学和代谢组学）。此次收购加强了大学和地区的研究基础设施。该仪器通过使不同的学生熟悉这种现代分析技术来扩大参与。HPLC-IM-Q-TOF还用于Susquehanna大学学生参与的外联活动。授予质谱仪的目的是加强各级的研究和教育。它尤其影响了超分子主客体化学的探索和多孔和结晶共价有机框架（COF）形成的机理研究。该仪器用于通过金属相互作用控制肽二级结构。此外，它提供了信息，以了解复杂的有机薄膜的多相化学。质谱仪用于探索三手烟对室内表面的影响，并用于研究药物的光降解。该仪器还用于识别萤火虫中的抗菌剂。该奖项反映了NSF的法定使命，并且通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Sulfide-linked 3,4,5-trimethoxyphenyl-thiosemicarbazide/triazole hybrids: Synthesis, antioxidant, antiglycation, DNA cleavage and DNA molecular docking studies

• DOI: 10.1016/j.rechem.2023.100806
• 发表时间: 2023-01-31
• 期刊: RESULTS IN CHEMISTRY
• 影响因子: 2.3
• 作者: Bollinger, Ashton;Brandt, Olivia N.;Henry, Geneive E.
• 通讯作者: Henry, Geneive E.

Temporal changes in thirdhand cigarette smoke film composition and oxidation of co-existing surface film chemicals

• DOI: 10.1039/d3ea00142c
• 发表时间: 2024-03-14
• 期刊: ENVIRONMENTAL SCIENCE-ATMOSPHERES
• 作者: Hurlock，April M.;Collins，Douglas B.
• 通讯作者: Collins，Douglas B.

Chromene-based Schiff Base Ligand: DNA Interaction Studies and Characterization of Tetranuclear Zinc, Nickel and Iron Complexes

• DOI: 10.1016/j.ica.2022.121363
• 发表时间: 2022-12
• 期刊: Inorganica Chimica Acta
• 影响因子: 2.8
• 作者: Andrew J. Ressler;Olivia N. Brandt;A. Weaver;Jenna E. Poor;Anna Ream;Nicolas A. Summers;C. McMillen;N. Seeram;W. Dougherty;G. Henry

Determining sequential micellization steps of bile salts with multi-CMC modeling

使用多 CMC 建模确定胆汁盐的连续胶束化步骤

• DOI: 10.1016/j.jcis.2023.03.146
• 发表时间: 2023
• 期刊: Journal of Colloid and Interface Science
• 影响因子: 9.9
• 作者: Rovnyak, David;He, Jiayi;Kong, Sophie;Eckenroad, Kyle W.;Manley, Gregory A.;Geffert, Raeanne M.;Krout, Michael R.;Strein, Timothy G.
• 通讯作者: Strein, Timothy G.

Phenolic furanochromene hydrazone derivatives: Synthesis, antioxidant activity, ferroptosis inhibition, DNA cleavage and DNA molecular docking studies

酚醛呋喃色烯腙衍生物：合成、抗氧化活性、铁死亡抑制、DNA 裂解和 DNA 分子对接研究

• DOI: 10.1016/j.bmc.2022.117088
• 发表时间: 2022
• 期刊: Bioorganic & Medicinal Chemistry
• 影响因子: 3.5
• 作者: Saylor, Jessica L.;Basile, Olivia N.;Li, Huifang;Hunter, Lindsey M.;Weaver, Ashton;Shellenberger, Blake M.;Ann Tom, Lou;Ma, Hang;Seeram, Navindra P.;Henry, Geneive E.
• 通讯作者: Henry, Geneive E.