Finding the targets of natural products in complex botanical extracts.

许多植物被用于营养和传统医药目的，并已证明了基于证据的效果。然而，识别造成观察到的影响的单一化合物的标准方法失败了，因为它们依赖于具有单一目标的单一化合物，并且忽略了许多相互作用的化合物对许多目标的整体影响。在这一应用中，我们提出了一种新的方法来同时识别复杂植物提取物中许多化合物的分子靶标，并随后通过对植物提取物的基因表达的反应来验证它们。这项研究将彻底改变对植物的营养和药用效果的理解，并将使我们的合作伙伴加快商业化进程。

Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify the molecular targets of many compounds in complex plant extracts, along with their subsequent validation by responses in gene expression to the plant extract. This research will revolutionise understanding of the nutritional and medicinal effects of plants and will allow our partners to accelerate commercialisation.