Novel vaccines and serotyping scheme for Haemophilus parasuis

副猪嗜血杆菌新疫苗和血清分型方案。由副猪嗜血杆菌引起的格拉斯氏病是澳大利亚和海外养猪业的重大问题。目前治疗格拉斯氏病的方法是使用抗菌药和疫苗。然而，抗菌剂对除注射以外难以用药的幼猪(断奶仔猪)的效果有限，目前的疫苗仅对疫苗中包括的血清型具有保护作用。我们建议检查对自然感染的免疫反应，并确定潜在的候选疫苗，然后在疫苗试验中进行测试。APAI将专注于开发一种基于DNA的副猪嗜血杆菌分型方案。

Novel vaccines and serotyping scheme for Haemophilus parasuis. Glasser's disease, caused by the bacterium Haemophilus parasuis, is a significant problem in Australian and overseas pig industries. Current approaches to the management of Glassers disease utilise antibacterials and also vaccines. However, antibacterials are of limited effectiveness in juvenile pigs (weaners) that are difficult to medicate other than by injection, and current vaccines are only protective against the serotypes included in the vaccine. We propose to examine the immune response to natural infection and identify potential vaccine candidates which will then be tested in vaccine trials. The APAI will focus on developing a DNA-based typing scheme for H. parasuis.