Human environmental test chamber

所要求的最先进的环境测试舱有助于在安斯利博士的研究中推出新的研究主题-在休息、锻炼和睡眠期间在受控气候极端条件下检查人类生理学。拟议的小室提供了一种在大范围内系统地改变温度和/或低氧程度的手段，使得研究人类对温度和低氧等生理压力的适应和适应不良的研究。所请求的密封室将允许持续曝光长达两周。从历史上看，实地研究，特别是那些纵向设计的研究，很难控制，因为寒冷的温度、干燥的空气、高发病率的胃肠道症状、食物和液体摄入不足、疲惫以及通常在徒步旅行和在研究地点生活时遇到的由此产生的心理压力，都会改变人类的生理。这些问题使得在极端氧气温度下进行纵向研究变得困难；对于任何短期和长期受控的纵向研究，都需要一个容易接近和受控的实验室环境。此外，拟议的温控舱还将用作研究睡眠单元；该舱将配备一张床，以允许进行这些类型的研究。加拿大没有专门的睡眠研究实验室；拟议中的设备肯定会为睡眠研究设定一个新的加拿大标准。这个小室将提供方法来探索内源性昼夜节律起搏器在多大程度上对先前报道的调节人类脑血流的关键因素的日变化做出贡献。精心控制室内温度和光线，同时控制环境条件，将使我们能够研究脑血流调节中控制昼夜节律波动的机制。基础生理学家和临床科学家对这些机制都非常感兴趣。

The requested state-of-the-art environmental test chamber facilitates the launch of new research themes within Dr Ainslie's research - the examination of human physiology in controlled climatic extremes during rest, exercise and sleep. The proposed chamber provides a means to systematically alter temperature and/or the degree of hypoxia over a wide range, allowing the study of human adaptation and maladaptation to physiological stresses such as temperature and low oxygen. The requested chamber will allow for continuous exposures for up to two weeks in duration. Historically, field studies, particularly those of longitudinal design, are difficult to control because cold temperatures, dry air, high incidence of gastrointestinal symptoms, inadequate food and fluid intake, exhaustion and resultant psychological stress typically encountered while hiking to, and living at the study location all modify human physiology. These problems make longitudinal studies at extremes of temperature of oxygen difficult; an easily accessible and controlled laboratory environment is necessary for any short and longer term controlled longitudinal study. Moreover, the proposed temperature controlled chamber will also be used as research sleep unit; the chamber will be fitted with a bed to permit these types of studies. There are no dedicated research-only sleep laboratories in Canada; the proposed equipment would certainly set a new Canadian standard for sleep research. This chamber will provide the means to explore the degree to which the endogenous circadian pacemaker contributes to the previously reported diurnal changes in key factors that regulate brain blood flow in humans. Meticulous control of chamber temperature and light with concomitant control of environment conditions will enable the study of the mechanisms that control circadian rhythm fluctuations in brain blood flow regulation. These mechanisms are of profound interest to basic physiologists and clinical scientists alike.