Continuous non-invasive measurement of cardiovascular control responses to physical activity and postural challenge in humans

该请求涉及1）基于笔记本电脑的超声系统和随附的信号处理单元2）无创连续血压测量系统。 我的研究旨在揭示如何控制心脏的泵送和肌肉中血管的扩大和缩小，以向肌肉提供血液流动和氧气，并在人体活动期间保持血压。 在过去的6年里，本研究为55名研究生、本科生和研究助理提供了培训。 这项研究的关键是连续测量完整人体系统中心脏和血管尺寸、血压和肌肉血流量的非侵入性方法。 需要超声波设备来取代目前实验室中过时和失效的系统。 血压测量系统需要更换不再可用的借用设备。通过这一研究基础设施所取得的研究结果将确定心脏和血管功能和控制方面的局限性和“薄弱环节”，以支持人类身体活动期间的肌肉。 因此，这项基础研究为旨在了解各种疾病状态和人群中体力活动耐受性问题的研究方向提供了信息。 最终，这一基础科学将指导临床和生活方式干预措施的发展，促进加拿大人的最佳生活质量。

This request is for 1) A laptop based ultrasound system and accompanying signal processing unit 2) A non-invasive continuous blood pressure measuring system. My research aims to unravel how the pumping of the heart and the widening and narrowing of blood vessels in muscle is controlled to provide blood flow and oxygen to the muscles and maintain blood pressure during human physical activity. This research has provided training for 55 graduate students, undergraduate students and research associates over the past 6 years. Essential for this research are non-invasive methods of continuous measurement of heart and blood vessel dimensions, blood pressure and muscle blood flow in the intact human system. The ultrasound equipment is needed to replace the now obsolete and failing system currently in the laboratory. The blood pressure measuring system is required to replace borrowed equipment that is no longer available for use. Research findings made possible by this research infrastructure will identify limitations and "weak links" in the function and control of the heart and blood vessels in support of muscle during human physical activity. This basic research therefore informs the direction of research aimed at understanding problems with tolerance for physical activity experienced in various disease states and populations. Ultimately this basic science will guide the development of clinical and lifestyle interventions that promote the best quality of life of Canadians.