Integrated cardiovascular control responses to physical activity in humans

人类体力活动的综合心血管控制反应

• 批准号: 250367-2011
• 负责人: Tschakovsky, Michael
• 金额: $ 2.91万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514549
• 关键词: Integrated; cardiovascular; control; responses; physical

Our tolerance for physical activity plays an important role in our quality of life, and depends in part on how well our muscle's demand for oxygen is met. This requires that the cardiovascular system constantly adjusts blood flow to active muscles while maintaining arterial blood pressure. Accomplishing these goals requires the heart to adjust the amount of blood that it pumps into the blood vessels, and the blood vessels to widen or narrow to adjust how much blood (and therefore oxygen) flows to the muscle and other tissue. My research program focuses on finding answers to the fundamental questions "How do the heart and blood vessels work to deliver adequate amounts of oxygen to muscle during physical activity?" and "How does exercise training improve their ability to do so?" In particular my work has focused on how quickly the heart and blood vessels adjust when the intensity of physical activity increases or decreases, because most of our activities are characterized by continually changing intensity. The current specific objectives of this research program are to 1) identify different types of cardiovascular exercise responses between individuals and how well these predict differences in exercise tolerance, and 2) identify whether exercise training can improve how quickly and how much oxygen delivery to active muscle can increase, and if "all out" sprint type exercise is more effective at this. This research will provide important new findings that advance understanding of how our heart and blood vessels function to support physical activity. Such basic research is the springboard for future investigations aimed at understanding how this function may be impaired and therefore affect the quality of life of Canadians, and what can be done to prevent that.

我们对体力活动的耐受力对我们的生活质量起着重要作用，部分取决于我们肌肉对氧气的需求得到满足的程度。 这要求心血管系统不断调整流向活跃肌肉的血流量，同时维持动脉血压。 实现这些目标需要心脏调整泵入血管的血液量，并扩大或缩小血管以调整流向肌肉和其他组织的血液（以及氧气）量。 我的研究项目侧重于寻找基本问题的答案“心脏和血管如何在体育活动期间向肌肉提供足够的氧气？”以及“运动训练如何提高他们的能力？” 我的工作特别关注当体力活动强度增加或减少时心脏和血管的调整速度，因为我们大多数活动的特点是强度不断变化。 该研究计划目前的具体目标是 1) 确定个体之间不同类型的心血管运动反应以及这些反应对运动耐量差异的预测效果，以及 2) 确定运动训练是否可以提高活动肌肉的供氧速度和供氧量，以及“全力以赴”的冲刺型运动是否更有效。 这项研究将提供重要的新发现，促进我们对心脏和血管如何支持身体活动的理解。 此类基础研究是未来调查的跳板，旨在了解这种功能如何受损并因此影响加拿大人的生活质量，以及可以采取哪些措施来防止这种情况发生。