Studies in organic, bio-organic and medicinal chemistry

有机化学是一门研究生命物质和维持生存的生理过程的科学。有机小分子的合成一直是制药工业的基础，几十年来提供了神奇的药物来对抗广泛的疾病。学术研究为这一进程作出了贡献，通过基础工作描绘了结构，属性和功能之间的关系。在这一过程中，向青年男女提供了出色的培训，使他们能够继续为制药和生物技术公司开展更多针对目标和疾病的研究作出重要贡献，以发现更好的药物。我在蒙特利尔大学的研究小组多年来在培养高素质人才方面产生了重大影响。在近300名集团校友中，有一些人负责与各自公司一起发现和开发新的有效药物。那些谁选择了学术生涯继续在培养自己的学生卓越的传统。多年来，我的团队一直参与各种研究领域，这些研究可以被描述为生物学启发和化学驱动。特别有益的活动是药物（即药剂）原型的合成，作为具有对抗癌症、心血管疾病、细菌和病毒感染以及阿尔茨海默病等的有希望的活性的概念证明。工业合作伙伴从中受益匪浅。

Organic Chemistry is the science that deals with living matter and the physiological processes that sustain survival. The synthesis of small organic molecules has been the foundation of the pharmaceutical industry having provided miracle drugs to combat a wide-cross section of diseases over many decades. Academic research has contributed to this process through basic work delineating the relationship between structure, property and function. In the process, excellent training is provided to young men and women who go on to contribute in a significant way to more target- and disease-oriented research in pharmaceutical and biotech companies with the objective of discovering better medicines. My research group at the University of Montreal has had a significant impact in the training of highly qualified personnel over the years. Among the nearly 300 group alumni are those who were responsible for the discovery and development of new and effective medicines with their respective companies. Those who have chosen an academic career have continued the tradition of excellence in training their own students. Over the years, my group has been involved in diverse areas of research that can be described as biology-inspired and chemically-driven. A particularly rewarding activity has been the synthesis of drug (i.e. medicinal agent) prototypes as proofs of concept with promising activities against cancer, cardiovascular disease, bacterial and viral infection, and Alzheimer's disease among others. Industrial collaborating partners have greatly benefitted from this.