Control mechanisms in pulsatile blood flow: an engineering view

多年来，血液流动一直被严格地认为是一个独立的流体动力学（管道）系统，只受压力和流动的物理定律的影响。实际上，除了这些规律外，血流在任何时候都受到自主神经系统的控制和调节。造成这种情况的原因是，血液流动的研究传统上属于工程和数学领域，而自主神经系统的研究则严格属于生理学领域。在过去40年左右的时间里，我在第一个领域工作，并与另一个领域的研究进行了大量的合作，我相信我现在已经建立了足够的合作联系，使我能够将这两个系统结合起来。这一建议代表了这样做的研究方案。

For many years blood flow has been considered strictly as a stand-alone fluid dynamic (plumbing) system, subject to only the physical laws of pressure and flow. In reality, in addition to these laws, blood flow is at all times subject to control and regulation by the autonomic nervous system. The reason for this situation is that the study of blood flow has traditionally been in the domain of engineering and mathematics while the study of the autonomic nervous system has been strictly in the domain of physiology. Having worked in the first of these domains in the last 4 decades or so, with considerable collaborative work with researches in the other domain, I believe I have now established sufficient collaborative links to enable me to put these two systems together. This proposal represents a research program for doing so.