Analysis of the Role of Snapin in the Regulation of SNARE Complex Assembly

Snapin在SNARE复合体组装调控中的作用分析这项拟议的研究的目的是调查蛋白质、管理单元蛋白在哺乳动物细胞内不同隔室之间的膜和货物蛋白运输中所起的作用。膜转运是一个基本的细胞过程，需要一系列被称为圈套的相关分子。我们最近发现Snapin与SNARE家族的某些成员相互作用，这意味着Snapin在膜运输中起着关键作用。拟议的研究将为Snapin和SNARs功能的潜在分子机制以及一般的膜运输提供重要的新见解。

Analysis of the Role of Snapin in the Regulation of SNARE Complex Assembly. The aims of the proposed studies are to investigate the role played by a protein, snapin in the trafficking of membranes and cargo proteins between different compartments inside mammalian cells. Membrane trafficking is a fundamental cellular process that requires a family of related molecules termed SNARES. We have recently discovered that snapin interacts with certain members of the SNARE family, implying a critical role in membrane trafficking. The proposed studies will provide important new insights into the molecular mechanisms underlying the function of both snapin and SNAREs, and membrane trafficking in general.