Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein

红系分化相关因子：一种新的a-珠蛋白结合蛋白的特性。血红蛋白是一种由四个亚基组成的蛋白质，由两个α多肽链和两个β多肽链组成，是所有哺乳动物中发现的基本氧转运蛋白。血红蛋白合成方面的问题可能会导致一系列常见和严重的人类疾病，包括地中海贫血症和贫血。我们已经发现了一种名为EDRF的蛋白质，它似乎直接与α-珠蛋白(而不是β-珠蛋白)相互作用，并在调节血红蛋白的产生中发挥作用。我们现在试图在分子水平和机制水平上理解这种相互作用的本质。

Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein. Hemoglobin, a four-subunit protein comprising two alpha and two beta polypeptide chains, is the essential oxygen transporter found in all mammals. Problems with the synthesis of hemoglobin can give rise to a range of common and serious human disorders, including thalassaemia and anemia. We have discovered a protein, EDRF, that appears to interact directly with alpha-globin (but not beta-globin) and to play a role in the regulation of hemoglobin production. We now seek to understand the nature of this interaction at a molecular level and mechanistic level.