Chemotherapy-induced peripheral neuropathy in the pediatric population: risk factors, assessment strategies and functional outcomes

化疗，常用于治疗儿童癌症，可引起周围神经损伤，致残症状可能持续很长时间。本项目旨在提供神经损伤的综合评价，规范神经功能的灵敏测量方法。这是第一个在整个治疗周期中对儿童进行定期神经评估的研究，提供了对神经损伤机制的更好理解，并使治疗调整成为可能。

Chemotherapy, commonly used for treatment of childhood cancer, can cause peripheral nerve injury with disabling symptoms which may be long lasting. This project aims to provide a comprehensive evaluation of the nerve injury and standardize sensitive ways of measuring nerve function. This is the first study that will follow children throughout their treatment cycle with regular nerve assessments, providing a greater understanding of nerve injury mechanisms and enabling treatment modification.