The Immunoregulatory Role of the Endogenous Cannabinoid Anandamide

内源性大麻素双胺的免疫调节作用。花生胺是一种天然存在的脂肪酸，作用于大脑和外周表达的大麻素受体。我们的研究小组提出的一项新建议挑战了传统的疾病过程模型，认为双胺系统是一个重要的免疫调节系统，可以作为入侵病原体的靶点。我们认为，通过作用于受体的细菌或病毒来阻断免疫反应，破坏anandamide系统，有助于慢性疾病状态。在这一点上，我们有很好的证据表明烷胺类药物是免疫调节剂，然而，我们对它们的确切生理作用知之甚少。这项研究的目的是开始描述双胺系统的免疫调节作用。该项目将提供对这种内源性控制系统的全面了解，其免疫学特性以前从未被描述过。这项研究的结果可能导致为开发针对这一系统的药物干预措施确定新的途径。

The Immunoregulatory Role of the Endogenous Cannabinoid Anandamide. Anandamides are naturally occurring fatty acids that act at the cannabinoid receptor expressed in the brain and periphery. A new proposal by our research group challenges traditional models of the disease process by suggesting that the anandamide system is an important imunoregulatory system that can be targeted by invading pathogens. We propose that disruption to the anandamide system, by bacteria or viruses acting at the receptor to block immunological responses, contributes to chronic illness states. At this point we have good evidence that anandamides are immunoregulators, however, we have very little knowledge of their precise physiological role. The aim of this research is to begin to characterise the immunoregulatory role of the anandamide system. This project will provide a comprehensive understanding of this endogenous control system, the immunological properties of which have not previously been described. The outcome of this research may lead to the identification of new avenues for the development of pharmaceutical interventions that can target this system.