Phosphorylation of Nck

人体由各种组织组成，而这些组织又由具有特殊功能的细胞组成。人体细胞功能的协调调节涉及调节细胞蛋白质活性的生化过程。一种影响蛋白质活性的重要修饰涉及到被定义为蛋白激酶的特殊酶对这些特定蛋白质的磷酸化。我们的实验室对蛋白质磷酸化的基础研究和参与这一过程的蛋白激酶的鉴定很感兴趣。作为一个工作模型，我们专注于我们发现的在各种胁迫条件下严重磷酸化的小蛋白Nck，已知的是激活特定的蛋白激酶子集。我们的研究将提供对调节人类细胞功能的基本机制的详细了解，从而使整个科学界受益。

The human body is composed of various tissues, which in turn consist of cells that have specialized functions. The coordinated regulation of the human cell functions involves biochemical processes mediating the modification of the activity of cellular proteins. One such important modification that affects protein activity implicates the phosphorylation of these specific proteins by specialized enzymes that are defined as protein kinases. Our laboratory is interested in the basic study of protein phosphorylation and in the identification of the protein kinases participating in this process. As a working model, we focus on the small protein Nck that we have found heavily phosphorylated in various stress conditions known to activate a specific subset of protein kinases. Our research will benefit the whole scientific community by providing a detailed understanding of fundamental mechanisms regulating the human cell functions.