Thermal and non-thermal influences on post-exercise thermoregulation

近年来，几项研究表明，运动停止后，人体核心温度调节会出现紊乱。在运动后，尽管身体核心温度持续升高，但皮肤血流量和出汗水平恢复到静息水平，这表明体温调节控制发生了变化。最近的研究表明，与运动后血流动力学变化相关的非热学因素可能会影响运动恢复过程中身体核心温度的调节。体力消耗后的体温调节反应受损在工作环境中是相当令人担忧的，因为与之相关的体力消耗后热相关损伤的风险增加。我的研究计划旨在1)了解运动后热平衡障碍的病因；2)评估可能导致这种长期高温状态的热和非热因素。建议的研究将旨在调查在单次和间歇性运动中，热因素和非热因素对身体核心温度调节的单独和综合影响，以及作为可能改变这种反应的不同生物医学因素(即性别、年龄、身体素质、热适应)的函数。这项研究计划的独特之处在于，它试图通过使用全身热量计直接测量产热和热损失的各个组成部分，来表征同时进行的热和非热反射的综合反应。研究人体不由自主地引起的促进热量散失的生理反应，并通过量热法直接测量随后对环境的热交换，将有助于更好地理解热应激是如何发展的。这可能会使人们能够更早地预测其发病。此外，通过考虑影响热平衡的生物医学特征的相对影响，我们还将能够开发更全面的风险评估数据，用于验证更适合个人的现有预测性热应激模型。

In recent years several studies have suggested that a disturbance in body core temperature regulation occurs following the cessation of exercise. In the post-exercise period the levels of skin blood flow and sweating return to resting levels despite a persistent elevation in body core temperature, suggesting an alteration in thermoregulatory control. Recent work has shown that non-thermal factors, associated with hemodynamic changes post-exercise may influence the regulation of body core temperature during exercise recovery. A compromised thermoregulatory response following physical exertion is of considerable concern within a working environment due to the associated increased risk of post-exertional heat-related injury. My research program is aimed at 1) understanding the etiology of the post-exercise disturbance in thermal homeostasis; and 2) evaluating the possible thermal and non-thermal factors which may contribute to this prolonged hyperthermic state. The proposed studies will be directed at investigating the separate and integrated influences of thermal and non-thermal factors on body core temperature regulation during single and intermittent bouts of exercise; and as a function of different biomedical factors which could alter this response (i.e., sex, age, physical fitness, heat acclimation). The design of this research program is unique in its attempt to characterize the integrated responses of simultaneous thermal and non-thermal reflexes by directly measuring the individual components of heat production and heat loss using a whole-body calorimeter. Studying the physiological responses elicited involuntarily by the human body to promote the dissipation of heat and directly measuring the subsequent heat exchange to the environment via calorimetry, will allow a better understanding of how heat stress develops. This will potentially allow for earlier prediction of its onset. Further, by considering the relative influence of biomedical characteristics affecting heat balance, we will also be able to develop a more comprehensive risk assessment data that could be used to validate existing predictive heat stress models that would be more tailored to the individual.