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Comparative biology of phagocytic antimicrobial responses

Comparative biology of phagocytic antimicrobial responses
吞噬抗菌反应的比较生物学
批准号:
355303-2008
负责人:
Barreda, Daniel
金额:
$2.44万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-01-01 至 2012-12-31

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中文摘要
翻译
动物宿主发动有效免疫应答的能力需要先天免疫和适应性免疫的精细交叉调节。偏离这些反应的无缝整合形成了自身免疫性疾病的基础,并对宿主对病原微生物的易感性产生了严重影响。目前的教条认为,进化的压力导致了免疫反应的适应性臂的发展,它必须小心地覆盖在已经建立的先天免疫机制上。我们的长期目标是了解这些桥梁是如何形成的。
英文摘要
The ability of an animal host to mount effective immune responses requires the exquisite cross-regulation of innate and adaptive arms of immunity. Deviation from the seamless integration of these responses forms the basis for autoimmune diseases and has serious implications for the susceptibility of the host to pathogenic microorganisms. The current dogma states that evolutionary pressures led to the development of the adaptive arm of the immune response, which had to carefully overlay onto already well-established innate mechanisms of immunity. Our long-term goal is to understand how these bridges were formed.
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Evolutionary adaptations in the induction and control of acute inflammation
  • 批准号:
    RGPIN-2018-05768
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $9.47万
  • 财政年份:
    2022
  • 负责人:
    Barreda, Daniel
  • 依托单位:
Evolutionary adaptations in the induction and control of acute inflammation
  • 批准号:
    RGPIN-2018-05768
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.74万
  • 财政年份:
    2021
  • 负责人:
    Barreda, Daniel
  • 依托单位:
Evolutionary adaptations in the induction and control of acute inflammation
  • 批准号:
    RGPIN-2018-05768
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.74万
  • 财政年份:
    2020
  • 负责人:
    Barreda, Daniel
  • 依托单位:
Custom platform for evaluation of conserved mechanisms of fever
  • 批准号:
    RTI-2020-00353
  • 项目类别:
    Research Tools and Instruments
  • 资助金额:
    $6.55万
  • 财政年份:
    2019
  • 负责人:
    Barreda, Daniel
  • 依托单位:
国内基金
海外基金
组蛋白乙酰化修饰ATG13激活自噬在牵张应力介导骨缝Gli1+干细胞成骨中的机制研究
  • 批准号:
    82370988
  • 项目类别:
    面上项目
  • 资助金额:
    48.00万元
  • 批准年份:
    2023
  • 负责人:
    经典
  • 依托单位:
Journal of Integrative Plant Biology
  • 批准号:
    31024801
  • 项目类别:
    专项基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2010
  • 负责人:
    贺萍
  • 依托单位:
Computational Methods for Analyzing Toponome Data