SARS-CoV-2-induced dead cell fragments drive viral uptake and inflammation

该项目将应用先进的细胞生物学和成像技术，研究缺乏病毒进入典型受体的巨噬细胞如何感染严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）并引发炎症反应。它对病毒进入新途径的见解有望促进我们对宿主-病原体相互作用的理解。该项目旨在揭示sars - cov -2诱导的死细胞分裂在促进病毒摄取和炎症中的作用。其研究结果将为感染和先天免疫的新研究方向以及未来感染治疗的治疗设计提供重要的科学、健康和经济效益。

This project will apply advanced cell biology and imaging techniques to investigate how macrophages, which lacks a canonical receptor for viral entry, become infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and elicit inflammatory responses. Its insights into a novel pathway of viral entry is expected to advance our understanding of host-pathogen interaction. The project is intended to uncover the role of SARS-CoV-2-induced dead cell fragmentation in promoting viral uptake and inflammation. Its findings should provide significant scientific, health and economic benefits by informing new research directions on infection and innate immunity as well as future therapeutic designs for infection treatment.