Affinity Reagents for the Immune System of Golden Hamster (for SARS-CoV-2 induced long-COVID disease)

金仓鼠免疫系统亲和试剂（针对SARS-CoV-2诱导的长效新冠病毒疾病）

• 批准号: 10933277
• 负责人: HONG QI
• 金额: $ 60万
• 依托单位: QOOLABS, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10933277
• 关键词: 2019-nCoV; Affinity; Antibodies; Antigens; Binding; Cells; Disease; Hamsters; Immune; Immune system; Immunization; Immunologic Markers; Long COVID; Mesocricetus auratus; Methods; Modeling; Monoclonal Antibodies; Oryctolagus cuniculus; Production; Reagent; Recombinant Proteins; Research; Technology

QooLabs proposes to generate high-affinity monoclonal antibodies against six immune cell targets of Syrian golden hamsters that are relevant to long-COVID research. Specifically, the Offeror proposes to produce recombinant proteins as immunogens for immunization of rabbits, to generate rabbit monoclonal antibodies using their proprietary method, and to validate the antibodies for use in long-COVID research in the hamster model for SARS-CoV-2.

QooLabs建议针对叙利亚金仓鼠的六个免疫细胞靶点产生高亲和力单克隆抗体，这些靶点与长期COVID研究相关。具体而言，要约人提出生产重组蛋白作为免疫原用于免疫兔子，使用其专有方法产生兔子单克隆抗体，并验证抗体用于SARS-CoV-2仓鼠模型中的长期COVID研究。