The first characterization of functional CYP450 activities in human cardiac myocytes: Modulation of cardiac potassium channel block due to the local metabolism of QT-prolonging drugs.
The first characterization of functional CYP450 activities in human cardiac myocytes: Modulation of cardiac potassium channel block due to the local metabolism of QT-prolonging drugs.
人类心肌细胞中功能性 CYP450 活性的首次表征：由于 QT 延长药物的局部代谢而调节心脏钾通道阻滞。
批准号：
238460
负责人：
Turgeon Jacques
金额：
$58.79万
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-09-01 至 2016-09-01
中文摘要
翻译
传统的药代动力学概念认为，肝脏和肠道中的酶（cyp450）是全身暴露于药物的关键决定因素。此外，组织中游离药物浓度也是一个需要考虑的重要因素
英文摘要
Conventional concepts in pharmacokinetics propose that enzymes (CYP450s) in the liver and intestines are key determinants of the systemic exposure to a drug. As well, it is known that the free drug concentration in tissues is an important factor to consid
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会议论文
Characterization of novel pathogenic roles of CYP450s in breast cancer
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批准号：199361
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项目类别：Operating Grants
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资助金额：$7.29万
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财政年份：2009
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负责人：Turgeon Jacques
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依托单位：
海外基金
