"Atomic Force Microscope for Drug Delivery, Li-ion Battery and Electronics Materials Research"

了解药代动力学、药效学和免疫原性是现代医学设计和合成新型给药系统的关键。 滑铁卢大学在药物递送研究方面做出了广泛的努力，主题包括有效递送载体的设计、药物和载体分子之间的相互作用、载体靶向和生物识别、有效卸载和药物释放以及体外药物递送功效。这里提出的其他研究是关于锂离子电池和先进的电子材料，其中精确的材料设计和电极，印刷有机电子和集成电路的制造需要高分辨率的成像和操作。 目前的5名申请人处于各自学科的前沿，积极参与药物输送和微电子系统开发的各个方面。 所要求的设备是一个多用途的原子力显微镜，它允许同时纳入显微镜技术和单点光谱，电力和电位传感技术在一个原子力显微镜单元，提供的能力，以定位载体药物复合物内的培养细胞，并指导微电子器件的分子设计。 超过50名研究生和博士后研究员将接受培训，并在多学科研究环境中使用所要求的AFM。

Understanding pharmacokinetics, pharmacodynamics and immunogenicity is a key to the design and synthesis of novel drug delivery systems for modern medicine. There exist extensive efforts in drug delivery studies at the University of Waterloo, topics including design of effective delivery vehicles, interaction between drug and vehicle molecules, vehicle targeting and biorecognition, effective unloading and drug release, and in vitro drug delivery efficacy. Other research proposed here is on lithium-ion batteries and advanced electronics materials, where precise material design and fabrication of electrodes, printed organic electronics and integrated circuits require high resolution imaging and manipulation. The current 5 applicants are at the forefront of their respective disciplines, and actively involved in various aspects of the development of drug delivery and microelectronics systems. The requested equipment is a multipurpose atomic force microscope; it allows the simultaneous incorporation of microscopic techniques and single-point spectroscopic, electric and potential sensing techniques in one AFM unit, providing the ability to locate the carrier-drug complexes inside the cultured cell, and guide the molecular design of microelectronics devices. Over 50 graduate students and post doctoral fellows will be trained with and using the requested AFM in a multidisciplinary research environment.