Factors influencing central and peripheral fatigue

本研究的重点是研究运动中影响中枢（脑）和外周（肌肉）疲劳的因素。有人提出，在体力劳动中，中枢和外周因素都有助于人类的疲劳。然而，目前尚不清楚的是这些因素中的每一个对疲劳的贡献。 在这项研究中，在不同类型的力竭运动和不同的环境条件下（例如，运动后），将监测大脑和肌肉的氧提取和血流量。缺氧或氧气减少、体温升高、衰老、健康状况）。 希望这些信息将增加我们对负责向大脑和肌肉输送氧气和血液的生物机制的理解。了解这一点对于我们理解人类表现的极限，以及与老年人大脑和肌肉健康以及慢性疾病相关的问题，以提高他们的生活质量具有重要意义。

The focus of this research is to study the factors that influence central (brain) and peripheral (muscle) fatigue during exercise. It is proposed that both central and peripheral factors contribute to fatigue in humans during physical work. However, what is not known is the contribution of each of these factors to fatigue. In this research, oxygen extraction and blood flow will be monitored in both the brain and the muscle during different types of exhaustive exercise and under different environmental conditions (eg. hypoxia or reduced oxygen, increased body temperature, ageing, fitness status). It is hoped that this information will increase our understanding of the biological mechanisms responsible for oxygen and blood delivery to the brain and muscle. Knowing this has important implications for our understanding of the limits of human performance, and issues related to brain and muscle health in the elderly and chronic disease to enhance their quality of life.