Central Mechanisms Influencing Hypertension

影响高血压的中心机制

• 批准号: nhmrc : 1109902
• 负责人: Dr Pamela Davern
• 金额: $ 28.84万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/central-mechanisms-influencing-hypertension/663101
• 关键词: Central; Mechanisms; Influencing; Hypertension

This proposal aims to examine central mechanisms important in stress related hypertension. My team will focus on the role of tissue plasminogen activator in mediating inhibitory effects of chronic stress on neural plasticity and examine inhibitory dysfunction in GABAergic and nitric oxide pathways that lead to increased sympathetic activity and elevated blood pressure. Importantly, we will investigate the potential of three interventions directed at each as therapies for hypertension.

本研究旨在探讨应激性高血压的中枢机制。我的团队将专注于组织纤溶酶原激活剂在介导慢性应激对神经可塑性的抑制作用中的作用，并检查导致交感神经活动增加和血压升高的GABA能和一氧化氮通路的抑制功能障碍。重要的是，我们将研究针对每种高血压治疗的三种干预措施的潜力。