Designing and fabricating artificial blood cells for global shortages

该项目旨在通过制造模仿红细胞复杂层的新型合成颗粒，创造出第一个生物物理上精确的人造血细胞。利用工程和生物学的创新方法，该项目有望推进生物合成微粒的生物制造技术。该项目的预期成果包括开发一种便携式、经济高效的平台技术，以立即推进对细胞膜动力学、相互作用和完整性的基础理解。我们预计，新的生物工程血液产品将为血液储存和输血提供重大的未来效益，包括可能缓解全球血液短缺。

This project aims to create the first biophysically accurate artificial blood cells through fabrication of novel synthetic particles that mimic the complex layers of red blood cells. Using innovative methods from engineering and biology, this project expects to advance biofabrication techniques for biosynthetic microparticles. Expected outcomes from this project include the development of a portable, cost-effective platform technology to immediately advance foundational understanding of cell membrane dynamics, interactions, and integrity. We anticipate that the new bioengineered blood product will provide significant future benefits for blood storage and transfusion, including potentially alleviating global blood shortages.