Studies in organic, bio-organic and medicinal chemistry

有机化学是研究生物物质和维持生存的生理过程的科学。几十年来，小有机分子的合成一直是制药业的基础，为对抗各种各样的疾病提供了神奇的药物。学术研究通过描述结构、性质和功能之间关系的基本工作，对这一过程做出了贡献。在这一过程中，向青年男女提供了出色的培训，这些青年男女继续为制药和生物技术公司中更多以目标和疾病为导向的研究作出重大贡献，目的是发现更好的药物。多年来，我在蒙特利尔大学的研究小组在培养高素质人才方面产生了重大影响。在近300名集团校友中，有一些人在各自的公司负责发现和开发新的有效药物。那些选择了学术生涯的人在培养自己的学生方面延续了卓越的传统。多年来，我的团队参与了不同领域的研究，这些研究可以被描述为受生物学启发和化学驱动。一项特别有益的活动是合成药物（即药物制剂）原型，作为对癌症、心血管疾病、细菌和病毒感染以及阿尔茨海默病等有希望的活动的概念证明。工业合作伙伴从中受益匪浅。

Organic Chemistry is the science that deals with living matter and the physiological processes that sustain survival. The synthesis of small organic molecules has been the foundation of the pharmaceutical industry having provided miracle drugs to combat a wide-cross section of diseases over many decades. Academic research has contributed to this process through basic work delineating the relationship between structure, property and function. In the process, excellent training is provided to young men and women who go on to contribute in a significant way to more target- and disease-oriented research in pharmaceutical and biotech companies with the objective of discovering better medicines. My research group at the University of Montreal has had a significant impact in the training of highly qualified personnel over the years. Among the nearly 300 group alumni are those who were responsible for the discovery and development of new and effective medicines with their respective companies. Those who have chosen an academic career have continued the tradition of excellence in training their own students. Over the years, my group has been involved in diverse areas of research that can be described as biology-inspired and chemically-driven. A particularly rewarding activity has been the synthesis of drug (i.e. medicinal agent) prototypes as proofs of concept with promising activities against cancer, cardiovascular disease, bacterial and viral infection, and Alzheimer's disease among others. Industrial collaborating partners have greatly benefitted from this.