Advanced techniques for organic analysis

拟议的研究旨在开发新的和改进的有机化合物分析技术。该研究的主要方向将是高效多维分离技术的发展，包括全面的二维气相色谱（GC×GC）和液相色谱（LC×LC）。在这些技术中，样品的组分在以不同性质为特征的两个单独的柱（“维度”）中进行分离。这大大增加了在一个色谱柱中无法分离的组分在第二个色谱柱中分离的可能性。此外，在一次分析中可以分离的组分总数也大大增加。研究的目标包括通过新的方法提高分离的速度和效率。在GCxGC中，我们计划继续开发一种不需要任何耗材的新型热调制器（色谱柱之间的接口）。我们还将探索程序升温冷却的结合，以改善半挥发性化合物向第二柱的转移。

The research proposed aims at the development of new and improved techniques for the analysis of organic compounds. The main thrust of the research will be the advancement of high efficiency and multidimensional separations, including comprehensive two-dimensional gas chromatography (GC×GC) and liquid chromatography (LC×LC). In these techniques, components of the samples are subject to separation in two separate columns ("dimensions") characterized by different properties. This vastly increases the chance that components that could not be separated in one column will be separated in the second one. In addition, the total number of components that can be separated in a single analysis is dramatically increased. The goals of the research include increasing the speed and efficiency of the separations through novel approaches. In GCxGC, we plan to continue the development of a novel thermal modulator (interface between the columns) which does not require any consumables. We will also explore incorporation of programmed temperature cooling to improve transfer of semi-volatile compounds to the second column.