Thermal and non-thermal influences on post-exercise thermoregulation

近年来，一些研究表明，在停止运动后，身体核心温度调节会发生紊乱。在运动后，尽管身体核心温度持续升高，但皮肤血流量和出汗水平恢复到静止水平，这表明体温调节控制发生了变化。最近的研究表明，与运动后血流动力学变化相关的非热因素可能影响运动恢复过程中身体核心温度的调节。在工作环境中，由于运动后热相关损伤的风险增加，体力消耗后的体温调节反应受损是一个相当值得关注的问题。我的研究计划旨在1)了解运动后热稳态紊乱的病因；2)评估可能导致这种长期高温状态的热因素和非热因素。拟议的研究将旨在调查在单次和间歇运动期间，热因素和非热因素对核心温度调节的单独和综合影响；并作为不同生物医学因素的函数，可以改变这种反应（即，性别，年龄，身体健康，热适应）。这项研究计划的设计是独特的，它试图通过使用全身热量计直接测量热量产生和热量损失的单个组成部分，来表征同时热反射和非热反射的综合响应。研究人体不自觉地引起的促进热量散失的生理反应，并通过量热法直接测量随后与环境的热量交换，将有助于更好地了解热应激的发生过程。这将有可能更早地预测其发病。此外，通过考虑影响热平衡的生物医学特征的相对影响，我们还将能够开发更全面的风险评估数据，可用于验证现有的预测热应激模型，该模型将更适合个人。

In recent years several studies have suggested that a disturbance in body core temperature regulation occurs following the cessation of exercise. In the post-exercise period the levels of skin blood flow and sweating return to resting levels despite a persistent elevation in body core temperature, suggesting an alteration in thermoregulatory control. Recent work has shown that non-thermal factors, associated with hemodynamic changes post-exercise may influence the regulation of body core temperature during exercise recovery. A compromised thermoregulatory response following physical exertion is of considerable concern within a working environment due to the associated increased risk of post-exertional heat-related injury. My research program is aimed at 1) understanding the etiology of the post-exercise disturbance in thermal homeostasis; and 2) evaluating the possible thermal and non-thermal factors which may contribute to this prolonged hyperthermic state. The proposed studies will be directed at investigating the separate and integrated influences of thermal and non-thermal factors on body core temperature regulation during single and intermittent bouts of exercise; and as a function of different biomedical factors which could alter this response (i.e., sex, age, physical fitness, heat acclimation). The design of this research program is unique in its attempt to characterize the integrated responses of simultaneous thermal and non-thermal reflexes by directly measuring the individual components of heat production and heat loss using a whole-body calorimeter. Studying the physiological responses elicited involuntarily by the human body to promote the dissipation of heat and directly measuring the subsequent heat exchange to the environment via calorimetry, will allow a better understanding of how heat stress develops. This will potentially allow for earlier prediction of its onset. Further, by considering the relative influence of biomedical characteristics affecting heat balance, we will also be able to develop a more comprehensive risk assessment data that could be used to validate existing predictive heat stress models that would be more tailored to the individual.