Development of advanced photoacoustic, photothermal and photocarrier techniques and biosensors for biomedical, dental and optoelectonic diagnostics

拟议的研究包括四个不同的领域：1a)半导体硅污染研究和1b)使用激光光载子辐射（PCR）、调制电致发光（MEL）和动态锁定PCR和MEL成像（PCRI和MELI）技术的硅太阳能电池诊断。2)开发一种潜在的突破性地下深度选择仪器技术，非线性光声雷达/声纳（PAR）断层扫描技术，用于软组织癌性病变的高对比度、高信噪比和高分辨率地下深部成像。一旦完全开发，这项技术有可能提供超声质量的图像分辨率，并在健康和癌组织之间提供与磁共振成像（MRI）相媲美的对比，而成本只是磁共振成像（MRI）的一小部分。3)结合光热辐射（PTR）和调制发光（LUM）锁定成像技术的发展，用于早期龋病的实时评估。两台相机将用于捕获近红外相机（LUM）和热红外相机（PTR）的多频率图像。这项牙科成像项目的成功可能会导致一项突破性的安全牙科临床成像技术，以在临床环境中与电离x光片竞争。4)开发光声发光雷达/声纳（PAR-LUM）和新型光热辐射（PTR）发光雷达（LUM），用于地球和空间微重力失重环境下的早期骨质疏松症（废用性骨质疏松症）诊断。拟议的研究计划旨在(1)通过改进过程质量控制，提高加拿大在工业电子和替代能源技术方面的竞争力；(2)开发突破性技术和生物传感器仪器，以便尽早发现乳腺癌病变、骨质疏松症和牙齿脱矿龋齿等广泛存在的疾病；(3)在加拿大积极参与并必须继续在国际上竞争的关键工业和卫生部门领域，或在加拿大应该找到竞争机会的新增长领域，就多学科问题提供HQP高级培训。

The proposed research encompasses four distinct areas: 1a) semiconductor silicon contamination studies and 1b) Si solar-cell diagnostics using the technique of laser Photo-Carrier Radiometry (PCR), modulated electroluminescence (MEL) and dynamic lock-in PCR and MEL imaging (PCRI and MELI). 2) The development of a potentially breakthrough subsurface depth-selective instrumentation technique, the non-linear photo-acoustic radar/sonar (PAR) tomography for high-contrast, signal-to-noise ratio and resolution of deep subsurface imaging of cancerous lesions in soft tissues. When fully developed, this technology has the potential to deliver ultrasonic-quality image resolution, and to provide contrast between healthy and cancerous tissues rivaling that of magnetic resonance imaging (MRI) at a fraction of the cost. 3) The development of a combined photothermal radiometric (PTR) and modulated luminescence (LUM) lock-in imaging technique for real-time assessment of very early dental carious lesions. Two cameras will be used to capture multi-frequency images of LUM (near-IR camera) and of PTR (thermal-IR camera). The success of this dental imaging project may lead to a breakthrough safe dental clinical imaging technology to compete with ionizing X-radiographs in clinical settings. 4) The development of photoacoustic-luminescence radar/sonar (PAR-LUM) and a novel photothermal radiometric (PTR)-luminescence (LUM) radar, for very early bone osteoporosis diagnosis on Earth and in the weightless environment of space microgravity (disuse osteoporosis). The proposed research program is aimed at (1) boosting Canadian competitiveness in industrial electronics and alternative energy technologies through improved process quality control; (2) developing breakthrough techniques and biosensor instrumentation for the earliest possible detection of widespread diseases such as breast cancerous lesions, osteoporosis and dental demineralization caries; and (3) offering advanced training of HQP in multidisciplinary problems in key industrial and health sector areas in which Canada has an active presence and must continue competing internationally, or in new growth fields in which it should find opportunities to compete.