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Computationally predicting prokaryotic protein subcellular localization, using experimentally-based criteria

Computationally predicting prokaryotic protein subcellular localization, using experimentally-based criteria
使用基于实验的标准计算预测原核蛋白质亚细胞定位
批准号:
240644-2011
负责人:
Brinkman, Fiona
金额:
$4.42万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31

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中文摘要
翻译
计算预测位于细菌细胞表面的蛋白质在医学和农业中都有广泛的兴趣,以确定新的潜在可达的(表面暴露的)药物靶点、诊断标记物和候选疫苗。这种分析还有助于鉴定微生物的环境检测标记,鉴定耐热/耐寒古菌中工业感兴趣的蛋白质的稳定性,一般基因组注释和蛋白质组学实验的设计。在此之前,我领导了PSORTb的开发,这是目前最精确的细菌和古菌蛋白亚细胞定位的预测因子,包括细胞表面蛋白定位。
英文摘要
Computationally predicting proteins located on the surface of bacterial cells is of wide interest in both medicine and agriculture, to identify new potentially accessible (surface-exposed) drug targets, diagnostic markers, and vaccine candidates. Such analysis also aids identification of markers for environmental detection of microbes, characterization of proteins of industrial interest for their stability from thermo/cold tolerant Archaea, general genome annotation, and design of proteomic experiments. Previously, I led the development of PSORTb, which is currently the most precise predictor of bacterial and archaeal protein subcellular localization, including cell surface protein localization.
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Computationally predicting bacterial and archaeal protein subcellular localization, using experimentally-based criteria
  • 批准号:
    RGPIN-2016-05748
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.93万
  • 财政年份:
    2021
  • 负责人:
    Brinkman, Fiona
  • 依托单位:
Computationally predicting bacterial and archaeal protein subcellular localization, using experimentally-based criteria
  • 批准号:
    RGPIN-2016-05748
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.93万
  • 财政年份:
    2020
  • 负责人:
    Brinkman, Fiona
  • 依托单位:
Computationally predicting bacterial and archaeal protein subcellular localization, using experimentally-based criteria
  • 批准号:
    RGPIN-2016-05748
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.93万
  • 财政年份:
    2019
  • 负责人:
    Brinkman, Fiona
  • 依托单位:
Computationally predicting bacterial and archaeal protein subcellular localization, using experimentally-based criteria
  • 批准号:
    RGPIN-2016-05748
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.93万
  • 财政年份:
    2018
  • 负责人:
    Brinkman, Fiona
  • 依托单位:
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