"Three genomes, two organisms, one host: Interactions between the bacterium Wolbachia pipientis, its WO bacteriophage and Drosophila"

沃尔巴克氏杆菌是一种变形细菌，几百万年来一直与寄主昆虫保持共生关系。这些细菌存在于宿主细胞的细胞质内，特别是卵巢和睾丸的细胞内，因此是内共生体。关于沃尔巴克氏菌和苍蝇之间的这种关系，有几个有趣的方面，目前正在我的实验室进行检查。首先，宿主似乎没有意识到沃尔巴克氏菌的存在，因为它不会产生典型的抗细菌免疫反应。我的实验室一直在研究使这些细菌能够在宿主细胞内生存和复制的机制，我们已经证明，宿主和细菌合作可以减少活性氧物种(ROS)造成的潜在细胞和DNA损伤。在受感染的细胞中产生高水平的ROS，宿主和细菌的抗氧化酶都被招募来中和它们。这是第一次描述动物细胞和细菌之间的这种类型的合作。

Wolbachia pipientis are proteobacteria that have maintained symbiotic associations with host insects for millions of years. These bacteria exist within the cytoplasm of host cells, preferentially cells of the ovaries and testes, and are therefore endosymbionts. There are several intriguing aspects about this relationship between Wolbachia and flies which are currently being examined in my laboratory. First, the host does not seem to recognize the presence of Wolbachia because it does not mount a typical anti-bacterial immune response. My laboratory has been studying the mechanisms that enable these bacteria to survive and replicate inside host cells, and we have shown that the host and bacteria cooperate to reduce potential cellular and DNA damage caused by reactive oxygen species (ROS). ROS are generated at high levels in infected cells, and both host and bacterial antioxidant enzymes are recruited to neutralize them. This is the first time that cooperation of this type has been described between animal cells and bacteria.