Statistical Methods in the Design and Analysis of Clinical Trials and Assessment of Prediction with Patient-Specific Information

在接下来的五年里，我将开发新的方法来估计、测试和统计推断基于患者具体数据建立的预测模型的准确性。将研究具有各种类型审查的生存结果数据的预测误差，用于适应治愈和未治愈患者群体的治愈率模型以及高维数据。这项研究对正在预测患者预后、疾病类别或治疗反应的健康和医学研究人员很重要。它也是统计学方法论研究的一个重要领域，需要计算方法和理论的发展。我将培养一名处理这些统计挑战的博士生，以建立这一领域的研究，以实现实际应用和统计科学的进步。

In the next five years, I will develop new methods in estimation, testing and making statistical inference for the accuracy of prediction models built upon patient specific data. Prediction error will be studied for survival outcome data with various types of censoring, for cure-rate models which accommodate cured and uncured patient populations and for high dimensional data. The research is important for health and medical researchers who are making predictions for patients' prognostics, disease categories or responses to therapy. It is also an important area of methodological research in statistics in need of computational methods and theoretical development. I will train a Ph.D. student in dealing with these statistical challenges to build up the research in this area for both practical use and advancement of statistical science.