Anti-microbial scaffold materials for cutaneous wound healing

这项拟议的研究集中在开发用于修复皮肤慢性降解和感染的新型功能生物材料。慢性II型糖尿病患者的四肢皮肤会出现神经和敏感性的丧失，通常会导致皮肤上皮的侵蚀和溃疡。除了失去敏感性外，慢性溃疡还会使皮肤容易受到细菌感染，从而导致坏疽和截肢。此外，尽管皮肤和皮肤替代品在烧伤患者中使用已有很长时间，但仍存在疤痕问题，特别是涉及真皮和皮下脂肪组织的较深皮肤伤口。这种皮肤重建的成功策略关键取决于支架材料的可用性，这种支架材料(1)概括了天然的细胞外基质(ECM)环境(主要是胶原性基质，具有

This proposed research is focused on the development of new functional biomaterials for the repair of chronic degradation and infection of skin. Loss of nerves and sensitivity occur in the skin of extremities in chronic type II diabetes, often resulting in epithelial erosion and ulceration. In addition to the loss of sensitivity, the chronic ulceration renders the skin prone to bacterial infection that can lead to gangrene and amputations. In addition, although skin and skin substitutes have been around for a long time for use in burn patients, there are still issues with scarring, especially for deeper skin wounds that involve the dermis and sub-cutaneous fat tissue. Successful strategies for such reconstruction of skin depend crucially on the availability of scaffold materials that (1) recapitulate the native extracellular matrix (ECM) environment (a largely collagenous matrix with