IL-17RA and IL-17RC signaling in hematopoietic and non-hematopoietic cells

细胞死亡是哺乳动物细胞对环境刺激的生物反应的一个方面。多种病原微生物可引起细胞死亡。细胞死亡主要有两种类型：凋亡和坏死。感染后，细胞接收到不同的信号，走上不同的细胞死亡途径，不同死亡方式的利用和细胞死亡的速度对感染的结局有很大的影响。促炎细胞因子信号是哺乳动物细胞在感染过程中通过相应的细胞因子受体接收的一种主要信号。白细胞介素17 （IL-17）就是其中之一。本研究项目将研究IL-17受体（IL-17R）传递的信号如何控制两种不同类型细胞（非造血组织结构细胞和造血免疫细胞）在感染沙眼衣原体细胞内细菌时的细胞死亡程序。我们有充分的理由相信，IL-17R的两个亚基（IL-17RA和IL-17RC）可能在调节这一基本生物学过程中具有不同的作用。

Cell death is one aspect of biological responses that mammalian cells respond to environmental stimuli. A wide range of pathogenic microorganism can cause cell death. There are two major types of cell death, apoptosis and necrosis. Upon infection, the cells go on different cell death pathways when they receive different signals, and the utilization of different way of dying and the rate of cell death will have a great impact on the outcome of infection. Proinflammatory cytokine signals are a major type of signals that mammalian cells receive through corresponding cytokine receptors during infection. Interleukin 17 (IL-17) is one of them. This research program will examine how the signals transmitted by IL-17 receptor (IL-17R) control the cell death program in two different types of cells, non-hematopoietic tissue structure cells and hematopoietic immune cells, upon infection with an intracellular bacterium called Chlamydia trachomatis. We have good reasons to believe that two subunits (IL-17RA and IL-17RC) of IL-17R may have different roles in regulating this fundamental biological process.