The development of safer oncolytic poxviruses dependent on cellular dNTP synthesis
The development of safer oncolytic poxviruses dependent on cellular dNTP synthesis
批准号:
282191
负责人:
Evans David H
金额:
$54.53万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-03-01 至 2018-03-01
中文摘要
在转化的过程中,癌细胞会获得许多不同的突变。然而,这些突变有时会造成“阿喀琉斯之踵”,因为它们经常使癌细胞对病毒感染敏感。溶瘤病毒疗法试图治愈
英文摘要
During the process of transformation, a cancer cell acquires many different mutations. However, these mutations can sometimes create an "Achilles heel" in that they often render cancer cells sensitive to virus infection. Oncolytic virus therapies try to e
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会议论文
Poxvirus replication and recombination as drivers of genome evolution
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批准号:381571
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项目类别:Operating Grants
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资助金额:$61.3万
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财政年份:2018
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负责人:Evans David H
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依托单位:
Biochemical and genetic studies of the mechanism of poxvirus replication and recombination
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批准号:253292
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项目类别:Operating Grants
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资助金额:$42.4万
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财政年份:2012
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负责人:Evans David H
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依托单位:
海外基金